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1

Characterization of the drug-to-antibody ratio distribution for antibody–drug conjugates in plasma/serum

Xu, Keyang, Liu, Luna, Dere, Randall, Mai, Elaine, Erickson, Rebecca, Hendricks, Angela, Lin, Kedan, Junutula, Jagath R, Kaur, Surinder

Journal:

Year:

2013

Language:

english

File:

PDF, 1.42 MB

english, 2013

2

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Junutula, Jagath R, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S

Journal:

Nature Biotechnology

Year:

2008

Language:

english

File:

PDF, 357 KB

english, 2008

3

Site-specific antibody drug conjugates for cancer therapy

Panowski, Siler, Bhakta, Sunil, Raab, Helga, Polakis, Paul, Junutula, Jagath R

Journal:

Year:

2014

Language:

english

File:

PDF, 2.32 MB

english, 2014

4

Surface-Functionalized Carrier-Free Drug Nanorods for Leukemia

Krishnan, Vinu, Sarode, Apoorva, Bhatt, Rohit, Oliveira, Joshua D., Brown, Tyler D., Jiang, Y. P., Reddy Junutula, Jagath, Mitragotri, Samir

Journal:

Advanced Therapeutics

Year:

2018

Language:

english

File:

PDF, 1.19 MB

english, 2018

5

Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

Keyang Xu, Luna Liu, Ola M. Saad, Jakub Baudys, Lara Williams, Douglas Leipold, Ben Shen, Helga Raab, Jagath R. Junutula, Amy Kim, Surinder Kaur

Journal:

Analytical Biochemistry

Year:

2011

Language:

english

File:

PDF, 615 KB

english, 2011

6

His230 of serine hydroxymethyltransferase facilitates the proton abstraction step in catalysis

Rashmi Talwar, Junutula R. Jagath, N. Appaji Rao, H. S. Savithri

Journal:

Year:

2000

Language:

english

File:

PDF, 517 KB

english, 2000

7

Advancing the careers of life science professionals of Indian origin

Junutula, Jagath R, Raman, Praveena, Patel, Darshana, Butler, Holly, Jayasuriya, Anula

Journal:

Nature Biotechnology

Year:

2010

Language:

english

File:

PDF, 215 KB

english, 2010

8

Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase

Jin, Rongsheng, Junutula, Jagath R, Matern, Hugo T, Ervin, Karen E, Scheller, Richard H, Brunger, Axel T

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 686 KB

english, 2005

9

Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest

Kyei, George B, Vergne, Isabelle, Chua, Jennifer, Roberts, Esteban, Harris, James, Junutula, Jagath R, Deretic, Vojo

Journal:

The EMBO Journal

Year:

2006

Language:

english

File:

PDF, 441 KB

english, 2006

10

Molecular characterization of Rab11-FIP3 binding to ARF GTPases

Eric Schonteich, Manohar Pilli, Glenn C. Simon, Hugo T. Matern, Jagath R. Junutula, Danielle Sentz, Randall K. Holmes, Rytis Prekeris

Journal:

European Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 1.59 MB

english, 2007

11

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

Jagath R. Junutula, Sunil Bhakta, Helga Raab, Karen E. Ervin, Charles Eigenbrot, Richard Vandlen, Richard H. Scheller, Henry B. Lowman

Journal:

Journal of Immunological Methods

Year:

2008

Language:

english

File:

PDF, 915 KB

english, 2008

12

cDNA Cloning, Overexpression in Escherichia coli, Purification and Characterization of Sheep Liver Cytosolic Serine Hydroxymethyltransferase

Junutula Jagath-Reddy, Kaliannan Ganesan, Handanahal S. Savithri, Asis Datta, Naropantul Appaji Rao

Journal:

Year:

1995

Language:

english

File:

PDF, 642 KB

english, 1995

13

Importance of the Amino Terminus in Maintenance of Oligomeric Structure of Sheep Liver Cytosolic Serine Hydroxymethyltransferase

Junutula Reddy Jagath, Balasubramanya Sharma, Brahatheeswaran Bhaskar, Asis Datta, Naropantul Appaji Rao, Handanahal S. Savithri

Journal:

Year:

1997

Language:

english

File:

PDF, 955 KB

english, 1997

14

Conformational changes in the bacterial SRP receptor FtsY upon binding of guanine nucleotides and SRP

Junutula R Jagath, Marina V Rodnina, Wolfgang Wintermeyer

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 230 KB

english, 2000

15

Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET

Jeff N. Tinianow, Herman S. Gill, Annie Ogasawara, Judith E. Flores, Alexander N. Vanderbilt, Elizabeth Luis, Richard Vandlen, Martine Darwish, Jagath R. Junutula, Simon-P. Williams, Jan Marik

Journal:

Nuclear Medicine and Biology

Year:

2010

Language:

english

File:

PDF, 480 KB

english, 2010

16

TBC1D13 is a RAB35 Specific GAP that Plays an Important Role in GLUT4 Trafficking in Adipocytes

Jonathan R. Davey, Sean J. Humphrey, Jagath R. Junutula, Ashwini K. Mishra, David G. Lambright, David E. James, Jacqueline Stöckli

Journal:

Year:

2012

Language:

english

File:

PDF, 15.80 MB

english, 2012

17

Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria

Kuijl, Coenraad, Pilli, Manohar, Alahari, Suresh K, Janssen, Hans, Khoo, Poh-Sim, Ervin, Karen E, Calero, Monica, Jonnalagadda, Sobhanaditya, Scheller, Richard H, Neefjes, Jacques, Junutula, Jagath R

Journal:

The EMBO Journal

Year:

2013

Language:

english

File:

PDF, 1.64 MB

english, 2013

18

Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells

Jacob, A., Jing, J., Lee, J., Schedin, P., Gilbert, S. M., Peden, A. A., Junutula, J. R., Prekeris, R.

Journal:

Journal of Cell Science

Year:

2013

Language:

english

File:

PDF, 3.46 MB

english, 2013

19

Development of a semi-automated high throughput transient transfection system

Bos, Aaron B., Duque, Joseph N., Bhakta, Sunil, Farahi, Farzam, Chirdon, Lindsay A., Junutula, Jagath R., Harms, Peter D., Wong, Athena W.

Journal:

Journal of Biotechnology

Year:

2014

Language:

english

File:

PDF, 649 KB

english, 2014

20

Interaction of Guanine Nucleotides with the Signal Recognition Particle from Escherichia coli †

Jagath, Junutula R., Rodnina, Marina V., Lentzen, Georg, Wintermeyer, Wolfgang

Journal:

Year:

1998

Language:

english

File:

PDF, 89 KB

english, 1998

21

Characterization of the Role of the Rab GTPase-activating Protein AS160 in Insulin-regulated GLUT4 Trafficking

Larance, M., Ramm, G., Stockli, J., van Dam, E. M., Winata, S., Wasinger, V., Simpson, F., Graham, M., Junutula, J. R., Guilhaus, M., James, D. E.

Journal:

Journal of Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 970 KB

english, 2005

22

Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene

Westlake, C. J., Junutula, J. R., Simon, G. C., Pilli, M., Prekeris, R., Scheller, R. H., Jackson, P. K., Eldridge, A. G.

Journal:

Proceedings of the National Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 823 KB

english, 2007

23

Rab14 Is Involved in Membrane Trafficking between the Golgi Complex and Endosomes

Junutula, J. R.

Journal:

Molecular Biology of the Cell

Year:

2004

Language:

english

File:

PDF, 1023 KB

english, 2004

24

FIP1/RCP Binding to Golgin-97 Regulates Retrograde Transport from Recycling Endosomes to the trans-Golgi Network

Jing, J., Junutula, J. R., Wu, C., Burden, J., Matern, H., Peden, A. A., Prekeris, R.

Journal:

Molecular Biology of the Cell

Year:

2010

Language:

english

File:

PDF, 3.33 MB

english, 2010

25

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes

Tan, S.-X., Ng, Y., Meoli, C. C., Kumar, A., Khoo, P.-S., Fazakerley, D. J., Junutula, J. R., Vali, S., James, D. E., Stockli, J.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 3.06 MB

english, 2012

26

Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice

Hocking, Samantha L., Stewart, Rebecca L., Brandon, Amanda E., Suryana, Eurwin, Stuart, Ella, Baldwin, Emily M., Kolumam, Ganesh A., Modrusan, Zora, Junutula, Jagath R., Gunton, Jenny E., Medynskyj, M

Journal:

Year:

2015

Language:

english

File:

PDF, 3.83 MB

english, 2015

27

Membrane Curvature Protein Exhibits Interdomain Flexibility and Binds a Small GTPase

King, G. J., Stockli, J., Hu, S.-H., Winnen, B., Duprez, W. G. A., Meoli, C. C., Junutula, J. R., Jarrott, R. J., James, D. E., Whitten, A. E., Martin, J. L.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 3.35 MB

english, 2012

28

Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Junutula, J. R., Flagella, K. M., Graham, R. A., Parsons, K. L., Ha, E., Raab, H., Bhakta, S., Nguyen, T., Dugger, D. L., Li, G., Mai, E., Lewis Phillips, G. D., Hiraragi, H., Fuji, R. N., Tibbitts, J

Journal:

Clinical Cancer Research

Year:

2010

Language:

english

File:

PDF, 800 KB

english, 2010

29

Molecular Characterization of Rab11 Interactions with Members of the Family of Rab11-interacting Proteins

Junutula, J. R., Schonteich, E., Wilson, G. M., Peden, A. A., Scheller, R. H., Prekeris, R.

Journal:

Journal of Biological Chemistry

Year:

2004

Language:

english

File:

PDF, 893 KB

english, 2004

30

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/IGF-1 Signalling Pathway

S. Trefely, P. S. Khoo, J. R. Krycer, R. Chaudhuri, D. J. Fazakerley, B. L. Parker, G. Sultani, J. Lee, J. Stephan, E. Torres, K. Jung, C. Kuijl, D. E. James, J. R. Junutula, J. Stöckli

Year:

2015

Language:

english

File:

PDF, 6.96 MB

english, 2015

31

8 th Annual European Antibody Congress 2012

Beck, Alain, Carter, Paul J., Gerber, Hans-Peter, Lugovskoy, Alexey A., Wurch, Thierry, Junutula, Jagath R., Kontermann, Roland E, Mabry, Robert

Journal:

Year:

2013

Language:

english

File:

PDF, 736 KB

english, 2013

32

Emerging Role of ImmunoPET in Receptor Targeted Cancer Therapy

Marik, Jan, R. Junutula, Jagath

Journal:

Current Drug Delivery

Year:

2011

Language:

english

File:

PDF, 145 KB

english, 2011

33

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Pillow, Thomas H., Sadowsky, Jack D., Zhang, Donglu, Yu, Shang-Fan, Del Rosario, Geoffrey, Xu, Keyang, He, Jintang, Bhakta, Sunil, Ohri, Rachana, Kozak, Katherine R., Ha, Edward, Junutula, Jagath R.,

Journal:

Chemical Science

Year:

2016

Language:

english

File:

PDF, 818 KB

english, 2016

34

Asp-89: a critical residue in maintaining the oligomeric structure of sheep liver cytosolic serine hydroxymethyltransferase

KRISHNA RAO, J.V., JAGATH, Junutula R., SHARMA, Balasubramanya, APPAJI RAO, N., SAVITHRI, H.S.

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 131 KB

english, 1999

35

Role of Arg-401 of cytosolic serine hydroxymethyltransferase in subunit assembly and interaction with the substrate carboxy group

JAGATH, Junutula Reddy, RAO, Naropantul APPAJI, SAVITHRI, Handanahal SubbaRao

Journal:

Biochemical Journal

Year:

1997

Language:

english

File:

PDF, 370 KB

english, 1997

36

Asp-89: a critical residue in maintaining the oligomeric structure of sheep liver cytosolic serine hydroxymethyltransferase

KRISHNA RAO, J. V., JAGATH, Junutula R., SHARMA, Balasubramanya, APPAJI RAO, N., SAVITHRI, H. S.

Journal:

Biochemical Journal

Year:

1999

Language:

english

File:

PDF, 131 KB

english, 1999

37

Next-Generation Antibody-Drug Conjugates (ADCs) for Cancer Therapy

Junutula, Jagath Reddy, Gerber, Hans-Peter

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 142 KB

english, 2016

38

Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity

Chaudhuri, Rima, Khoo, Poh Sim, Tonks, Katherine, Junutula, Jagath R, Kolumam, Ganesh, Modrusan, Zora, Samocha-Bonet, Dorit, Meoli, Christopher C, Hocking, Samantha, Fazakerley, Daniel J, Stöckli, Jac

Journal:

npj Systems Biology and Applications

Year:

2015

Language:

english

File:

PDF, 3.59 MB

english, 2015

39

Design and Synthesis of Isoquinolidinobenzodiazepine Dimers, a Novel Class of Antibody–Drug Conjugate Payload

Smith, Sean W., Jammalamadaka, Vasu, Borkin, Dmitry, Zhu, Jianyu, Degrado, Sylvia J., Lu, Jennifer, Huang, Jianqing, Jiang, Ying-Ping, Jain, Nareshkumar, Junutula, Jagath R.

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.50 MB

english, 2017

40

Non-Invasive Imaging of Phosphoinositide-3-Kinase-Catalytic-Subunit-Alpha (PIK3CA) Promoter Modulation in Small Animal Models

Gaikwad, Snehal M., Gunjal, Lata, Junutula, Anitha R., Astanehe, Arezoo, Gambhir, Sanjiv Sam, Ray, Pritha, Pieper, Russell O.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.72 MB

english, 2013

41

Important role of the tetraloop region of 4.5S RNA in SRP binding to its receptor FtsY

JAGATH, JUNUTULA R., MATASSOVA, NATALIA B., DE LEEUW, ERIK, WARNECKE, JENS M., LENTZEN, GEORG, RODNINA, MARINA V., LUIRINK, JOEN, WINTERMEYER, WOLFGANG

Journal:

Year:

2001

Language:

english

File:

PDF, 400 KB

english, 2001

42

Important role of the tetraloop region of 4.5S RNA in SRP binding to its receptor FtsY

JAGATH, JUNUTULA R., MATASSOVA, NATALIA B., DE LEEUW, ERIK, WARNECKE, JENS M., LENTZEN, GEORG, RODNINA, MARINA V., LUIRINK, JOEN, WINTERMEYER, WOLFGANG

Journal:

Year:

2001

File:

PDF, 400 KB

2001